Brian Modena, MD


[email protected]

Assistant Professor, Scripps Translational Science Institute
Assistant Professor of Molecular Medicine, The Scripps Research Institute

Brian Modena, M.D. is a physician researcher with trained expertise in Allergy-Immunology, and a specific interest in treating patients with difficult to control asthma, allergic skin disorders, and immunologic deficiencies. His research interest involves the use of mRNA gene expression, epigenetic methylation changes, genetic variation, microbiome changes (‘dysbiosis’) and utilization of new health monitoring technologies to improve biological and clinical understanding of disease. The unifying interest in his research studies is the use of new research discoveries and technologies to deliver the most personalized medical care possible.

He joined the Scripps Translational Science Institute (STSI) in 2014 as a KL2 Clinical Scholar, and later joined STSI and TSRI as a joint Assistant Professor in 2016. He serves as a clinical preceptor to medical students and Allergy-Immunology fellows by maintaining a faculty appointment in the Scripps Health Allergy-Immunology Division.



Modena, Brian D Rachel Milam, Frank Harrison, Jennifer A Cheeseman, Michael M Abecassis, John Friedewald, Allan D. Kirk, Daniel R Salomon. Changes in urinary microbiome populations correlate in kidney transplants with interstitial fibrosis and tubular atrophy documented in early surveillance biopsies, American Journal of Transplantation (AJT). In Press. 2016.

Modena Brian, Sunil M Kurian, Lillian W Gaber, Jill Waalen, Terri Gelbart, Tony S Mondala, Steven R Head, Suzanne Papp, Raymond Heilman, John J Friedewald, Stuart Flechner, Christopher L Marsh, Randall S. Sung, Hamid Shidban, Laurence Chan, Michael M Abecassis, Daniel R Salomon. (2015). Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms that Correlate with Worse Long-term Outcomes. American Journal of Transplantation (AJT). March 15, 2016.

Modena, Brian, Kristen M Dazy, Andrew White (2016). Emerging Concepts: mast cell involvement in allergic diseases. Translational Research. Feb 24, 2016

Modena B, Tedrow J, Milosevic J, Bleecker E, Meyers D, Wu W, Bar-Joseph Z, Erzurum S, Gaston B, Busse W, Jarjour N, Kaminski N & Wenzel S. (2014). Gene Expression in Relation to Exhaled NO Identifies Novel Asthma Phenotypes with Unique Biomolecular Pathways. American Journal of Respiratory and Critical Care Medicine (AJRCCM). Vol. 190, No. 12 (2014), pp. 1363-1372. doi: 10.1164/rccm.201406-1099OC.

Cook K, Modena B, Simon R. (2016). Improvement in Asthma Control Using a Minimally Burdensome and Proactive Smartphone Application. The Journal of Allergy and Clinical Immunology (JACI): In Practice. Jul-Aug;4(4):730-737.e1. doi: 10.1016/j.jaip.2016.03.005.