This figure, published in Dr. Bansal’s 2010 Bioinformatics paper, illustrates how comparing allele counts across multiple DNA pools can be used to distinguish rare variants from sequencing errors.

CRISP is a software program designed by Vikas Bansal, Ph.D., to detect SNPs and short indels from pooled sequencing data. CRISP is designed to detect both rare and common variants by utilizing sequence reads from next-generation sequencing of multiple DNA pools.

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