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LeBeouf, Sarah, B.S.
Characteristics of cancer cell metabolism that can directly affect the development of an invasive and metastatic phenotype result in changes to the cellular redox potential. A key component of the cellular redox potential is the ratio of nicotinamide adenine dinucleotide, NAD+, to NADH. NAD+ is involved in redox reactions that participate in a broad spectrum of cellular processes, including signal transduction, gene transcription, DNA repair, and post-translational protein modifications.
As a TL-1 trainee, Sarah is investigating how changes in the cellular balance of NAD+ to NADH modulate tumor progression. She is determining what role the group of NAD+ dependent protein deacetylases called sirtuins have in cells with an altered NAD+/NADH ratio.
Before starting at TSRI, Sarah received her B.S. in Biology from the University of Texas at Austin. As an undergraduate, Sarah did research in the field of supramolecular analytical chemistry and completed her undergraduate thesis in developmental biology. In 2010 she was awarded a Dean’s Fellowship at TSRI. Sarah currently organizes the journal club for the biology program and serves on the graduate student committee.