Researchers from the Scripps Research Institute (TSRI) and the Scripps Translational Science Institute (STSI) have published a study that shows that genome-wide molecular profiling of kidney biopsies may be a key to catching organ rejection before it’s too late.
As outlined in a press release by TSRI, the research demonstrates that acute and chronic kidney rejection – currently believed to be separate diseases – are actually different parts of the arc of the same immune rejection process.
Dr. Brian Modena, a physician-scientist and KL2 Clinical Scholar at STSI, worked with Professor Daniel Salomon’s lab at TSRI to conduct this novel and important research study.
Read full press release by TSRI.
Read the study in the American Journal of Transplantation – Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes