Pilot Studies

The STSI Pilot/Methodological grants consist of awards for approximately $50,000 of direct funds directly relating to clinical and translational research that has the potential to impact the future of medicine.

Pilot Studies

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Awarded Pilot Grants

Featured Pilot Grant

Improving Visual Function in Patients with Age-related Macular Degeneration

Age-related macular degeneration (ARMD) is a degenerative retinal disorder, affecting nearly one third of patients over the age of 55 in the United States and other developed countries. In the early stages of this condition, patients complain of increasing difficulty reading, decreased visual sensitivity, loss of contrast sensitivity and poor dark adaptation. Widely publicized medications have revolutionized treatment of the angiogenic or “wet” form of the disease, but there is…

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Pilot Grants by Disease Target

Aging

Genetic dissection of heart function with age: Role of ILK and associated proteins


Autism

Pilot re-sequencing and characterization of variants on 5p14 in children with autism


Cancer

Characterization of embryonic stem cell markers on circulating tumor cells


Development of in vitro and in vivo systems for the metastatic analysis of stem and ...


Genetic Profiling for Guiding Breast Cancer Screening


Identification of recurrent gene fusions in solid tumors


Identifying miRNA signatures in blood and saliva for early detection of lung cancer


Investigation of New Inhibitors of Hyaluronidase-1 for Treatment of Cancer Progression


Mitochondrial complex I alterations in breast cancer


PRAK as an adjunctive marker for preoperative diagnosis of thyroid cancer


Role of Human Skin-Resident and Blood T Cells in Melanoma Surveillance


Synthetic Lethal Targets with Chromatin Remodeling Mutations in Cancer


Targeting B cell lymphomas with liposomes carrying glycan ligands of CD22


Targeting Hyaluronidase-1 for Treatment of Cancer Progression


Cardiology

Cytochrome Variant in CYP2C19 and Platelet Responsiveness to Clopidogrel


Genetic dissection of heart function with age: Role of ILK and associated proteins


Impact of Genotype on Platelet Function and Clinical Outcome after PCI: SEASIDE Substudy


Nanostructure-initiated MS as a new platform in atherosclerosis diagnostics


The Role of Mia2 in ApoA1 Secretion and HDL Biogenesis


Cystic Fibrosis

Biological Implications of Tetramic Acid


Contribution of P. aeruginosa cell cycle control to chronic infections


Dermatology

A novel therapeutic target for chronic inflammatory skin disorders


Diabetes

Skin T Cell Function in Diabetic Patients


Friedriech's Ataxia

Secondary Genetic Modifiers in Friedreich's Ataxia


Hematology

Investigation of YRSact as therapeutic agent for thrombocytopenia


Infectious Diseases

Clinical significance and therapeutic application of Pin1 anti-retroviral activity


Contribution of P. aeruginosa cell cycle control to chronic infections


HERV Activation in Primary HIV-1 Infection


Malaria

Citrulline as adjunctive therapy for severe malaria


Neurology

Identify genetic variations within thermoTRPs that affect pain & migraine in humans


LPA signaling in hydrocephalus


Mechanisms of Inflammation in Multiple Sclerosis


Role of 5-HT7 receptor gene polymorphisms on antidepressant response in bipolar disorder


Obesity

Regulation of adiponectin receptor 1 and 2 by leptin and insulin in the POA of the hypothalamus...


Opthalmology

Facilitating Exocytosis of Lipofuscin for the Treatment of Macular Degeneration


Improving Visual Function in Patients with Age-related Macular Degeneration


Novel treatment of Malattia Leventinese (ML) using protein kinase C (PKC) inhibitors


Toward the identification of an artificial chromophore to restore vision


Toward the Identification of an Artificial Chromophore to Restore Vision (Year 2)


Osteoporosis

Association of Plasma Serotonin (5HT), 5HT-related SNPs and Bone Mineral Density


Pulmonary Disease

Nanoparticles for Safe Reversal of Heparin Anticoagulation


Renal Disease

Role of Innate Immunity in Human Ischemic Renal Disease


Stem Cells

Induced Pluripotent Cells in Cartilage Injury and Repair


Vascular Disease

Discovery of Novel Plasma Biomarkers for VTE Risk