This section briefly describes several ongoing major studies as well as recently completed investigations. The Scripps Translational Science Institute also sponsors pilot/methodological studies whose potential impact on health care is significant. To learn about these projects, please visit Pilot Study Awards. The journal reports and other articles authored by STSI researchers also are a source of information about the institute’s studies.
The Scripps Genomic Health Initiative is the first large-scale and long-term evaluation of the attitudes and perceptions of consumers who have who have purchased a commercially available personal genomic risk assessment test. The initial results from the SGHI study were published online Jan. 12, 2011 by the New England Journal of Medicine.
Circulating endothelial cells are being investigated as a potential biomarker of increased risk for sudden heart attack. And, in a “gene desert” region on human chromosome 9, researchers are taking advantage of the relatively new research tool, zinc finger nucleases, and other groundbreaking new approaches, such as induced pluripotent stem cells, to identify DNA variants that increase risk for coronary artery disease.
The DNA sequences of different strains of methicillin-resistant Staphylococcus aureus (MRSA) are being scrutinized to identify genetic factors that distinguish the serious but treatable noninvasive form of the disease from the invasive and potentially lethal infections that bore through the skin, down to the bone, and spread to other body tissues.