Pilot Studies
The STSI Pilot/Methodological grants consist of awards for approximately $50,000 of direct funds directly relating to clinical and translational research that has the potential to impact the future of medicine.
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Awarded Pilot Grants
Featured Pilot Grant
Improving Visual Function in Patients with Age-related Macular Degeneration
Age-related macular degeneration (ARMD) is a degenerative retinal disorder, affecting nearly one third of patients over the age of 55 in the United States and other developed countries. In the early stages of this condition, patients complain of increasing difficulty reading, decreased visual sensitivity, loss of contrast sensitivity and poor dark adaptation. Widely publicized medications have revolutionized treatment of the angiogenic or “wet” form of the disease, but there is…
Pilot Grants by Disease Target
Aging
Genetic dissection of heart function with age: Role of ILK and associated proteins
Autism
Pilot re-sequencing and characterization of variants on 5p14 in children with autism
Cancer
Characterization of embryonic stem cell markers on circulating tumor cells
Development of in vitro and in vivo systems for the metastatic analysis of stem and ...
Genetic Profiling for Guiding Breast Cancer Screening
Identification of recurrent gene fusions in solid tumors
Identifying miRNA signatures in blood and saliva for early detection of lung cancer
Investigation of New Inhibitors of Hyaluronidase-1 for Treatment of Cancer Progression
Mitochondrial complex I alterations in breast cancer
PRAK as an adjunctive marker for preoperative diagnosis of thyroid cancer
Role of Human Skin-Resident and Blood T Cells in Melanoma Surveillance
Synthetic Lethal Targets with Chromatin Remodeling Mutations in Cancer
Targeting B cell lymphomas with liposomes carrying glycan ligands of CD22
Targeting Hyaluronidase-1 for Treatment of Cancer Progression
Cardiology
Cytochrome Variant in CYP2C19 and Platelet Responsiveness to Clopidogrel
Genetic dissection of heart function with age: Role of ILK and associated proteins
Impact of Genotype on Platelet Function and Clinical Outcome after PCI: SEASIDE Substudy
Nanostructure-initiated MS as a new platform in atherosclerosis diagnostics
The Role of Mia2 in ApoA1 Secretion and HDL Biogenesis
Cystic Fibrosis
Biological Implications of Tetramic Acid
Contribution of P. aeruginosa cell cycle control to chronic infections
Dermatology
A novel therapeutic target for chronic inflammatory skin disorders
Diabetes
Skin T Cell Function in Diabetic Patients
Friedriech's Ataxia
Secondary Genetic Modifiers in Friedreich's Ataxia
Hematology
Investigation of YRSact as therapeutic agent for thrombocytopenia
Infectious Diseases
Clinical significance and therapeutic application of Pin1 anti-retroviral activity
Contribution of P. aeruginosa cell cycle control to chronic infections
HERV Activation in Primary HIV-1 Infection
Malaria
Citrulline as adjunctive therapy for severe malaria
Neurology
Identify genetic variations within thermoTRPs that affect pain & migraine in humans
LPA signaling in hydrocephalus
Mechanisms of Inflammation in Multiple Sclerosis
Role of 5-HT7 receptor gene polymorphisms on antidepressant response in bipolar disorder
Obesity
Regulation of adiponectin receptor 1 and 2 by leptin and insulin in the POA of the hypothalamus...
Opthalmology
Facilitating Exocytosis of Lipofuscin for the Treatment of Macular Degeneration
Improving Visual Function in Patients with Age-related Macular Degeneration
Novel treatment of Malattia Leventinese (ML) using protein kinase C (PKC) inhibitors
Toward the identification of an artificial chromophore to restore vision
Toward the Identification of an Artificial Chromophore to Restore Vision (Year 2)
Osteoporosis
Association of Plasma Serotonin (5HT), 5HT-related SNPs and Bone Mineral Density
Pulmonary Disease
Nanoparticles for Safe Reversal of Heparin Anticoagulation
Renal Disease
Role of Innate Immunity in Human Ischemic Renal Disease
Stem Cells
Induced Pluripotent Cells in Cartilage Injury and Repair
Vascular Disease
Discovery of Novel Plasma Biomarkers for VTE Risk